By Karl Maramorosch, Frederick A. Murphy, Aaron J. Shatkin

ISBN-10: 0120398621

ISBN-13: 9780120398621

The Advances in Virus examine sequence covers a various diversity of in-depth reports supplying a worthy assessment of the present box of virology. This eclectic quantity comprises six experiences protecting themes in terms of plant viruses, evolution of viruses with hosts and phone attractiveness by means of viruses. Six accomplished reports on: * Varicella Virus - Mononuclear mobile interplay * Evolution of mobilephone attractiveness by means of Viruses: A resource of organic Novelty with clinical Implications * Infectious Pancreatic Necrosis Virus: Biology, Pathogenesis and Diagnostic tools * constructions of Picrona-like plant viruses: Implications and functions * Cucumoviruses * Co-Evolution of Viruses with Hosts and Vectors and attainable Paleontology

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Binding to heparin is a phenotypic trait displayed by several viruses propagated in cell culture, presumably because the interaction with HS residues may provide a selective advantage for viruses evolving in cultured cells (Section IV,B). , 1999). , 2001; Parkes and Hart, 2000). Interaction of adenovirus with v integrins has been reviewed (Nemerow and Stewart, 1999; Nemerow, 2000) (Table II). A variety of bacterial pathogens also use integrin receptors to either adhere to or enter into host cells.

A) Representation and comparison of the domain structure of ICAM-1 (CD54), the receptor for the major group rhinoviruses, and the poliovirus receptor (PVR or CD155). The immunoglobulin-like domains (labeled D1–D5 or D1–D3) are represented schematically by a circle closed by one or two disulfide bonds. The different Ig domains are linked by a flexible peptide chain. Hinge points are indicated by arrows. , 1999) virus is represented as a gray-scale surface. D1 and D2 domains of ICAM1 are colored red.

Virus population size: very variable but can reach 109 to 1012 in some infections in vivo 3. Genome length: 3 to 33 kb, with compact genetic information 4. Mutations needed for a phenotypic change: one or few mutations, as documented amply in the text for changes in receptor recognition specificity Examples of phenotypic changes in RNA viruses dependent on one or few mutations 1. Antigenic variation (antibody-, CTL-escape) 2. Virulence 3. Altered pattern of gene expression 4. Resistance to antiviral inhibitors 5.

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Advances in Virus Research, Vol. 62 by Karl Maramorosch, Frederick A. Murphy, Aaron J. Shatkin


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