By Joseph W. St. Geme III

ISBN-10: 3319437283

ISBN-13: 9783319437286

ISBN-10: 3319437291

ISBN-13: 9783319437293

This ebook describes the becoming physique of knowledge at the epidemiology, medical manifestations, transmission, pathogenesis, prognosis, and remedy of Kingella kingae infectionsin little ones. furthermore, it covers experimental equipment which have been constructed to review the microbiology, genetics, and virulence elements of K. kingae, info that offers the basis for brand new methods to therapy and prevention of K. kingae disease. With this content material in brain, excerpts from the ebook may be of relevance for clinicians who take care of pediatric sufferers, for medical microbiologists who're keen on detecting organisms in scientific specimens, and for scientists who're learning K. kingae in an attempt to enhance novel objectives for antimicrobial remedy and new techniques to prevention.

First remoted within the Nineteen Sixties via Elizabeth O. King, a bacteriologist on the CDC, Kingella kingae was once principally missed over the subsequent 20 years as a human pathogen as a result of its unusual restoration from sufferers with disorder. even if, lately K. kingae has been more and more well-known as a clinically vital pathogen in teenagers, and is at the moment well-known because the top reason for osteoarticular infections in youngsters in more and more nations. learn into this organism has grown significantly during the last 15 years, leading to a greater appreciation of the significance of K. kingae in pediatric sufferers and of the molecular mechanisms of illness.

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00311-11 48. Miajlovic H, Cooke NM, Moran GP, Rogers TR, Smith SG (2014) Response of extraintestinal pathogenic Escherichia coli to human serum reveals a protective role for Rcs-regulated exopolysaccharide colanic acid. Infect Immun 82(1):298–305. 00800-13 49. Simpson JA, Smith SE, Dean RT (1988) Alginate inhibition of the uptake of Pseudomonas aeruginosa by macrophages. J Gen Microbiol 134(1):29–36. 1099/00221287-134-1-29 50. Yagupsky P (2004) Kingella kingae: from medical rarity to an emerging paediatric pathogen.

Aust NZ J Ophthalmol 19(3):217–220 68. Munoz-Egea MC, Garcia-Pedrazuela M, Gonzalez-Pallares I, Martinez-Perez M, Fernandez-Roblas R, Esteban J (2013) Kingella kingae keratitis. J Clin Microbiol 51(5): 1627–1628. 03426-12 Pathogenesis of Kingella kingae Disease Eric A. Porsch and Katherine A. Rempe Colonization The pathogenesis of Kingella kingae disease is believed to begin with colonization of the oropharynx. In order to colonize this site, the organism must adhere to respiratory epithelial cells.

Yagupsky P, Greenberg D (2012) Kingella species. In: Long S (ed) Principles and practice of pediatric infectious diseases, 4th ed. , Edinburgh 3. Yagupsky P, Peled N, Katz O (2002) Epidemiological features of invasive Kingella kingae infections and respiratory carriage of the organism. J Clin Microbiol 40(11):4180–4184 4. Amit U, Flaishmakher S, Dagan R, Porat N, Yagupsky P (2014) Age-dependent carriage of Kingella kingae in young children and turnover of colonizing strains. J Pediatr Infect Dis Soc 3(2):160–162.

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Advances in Understanding Kingella kingae by Joseph W. St. Geme III

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